Research and Scholarship

Early Lung Cancer Treatment Improves Survival, Mortality Rates

Key research findings shared at AATS annual meeting

May 29, 2024

Dr. Jeffrey Velotta, KPSOM Clinical Science Faculty

Dr. Jeffrey Velotta, KPSOM Clinical Science Faculty

Advising patients on the optimal time to obtain lung cancer treatment for early-stage lung cancer has long been up for debate, but recent research findings from Drs. Jeffrey Velotta and Haley Tupper have helped physicians better identify this timing, which can directly improve patient mortality and survival rates.

The duo made news in the April 27 issue of the AATS Daily News , as Tupper – a University of California, Los Angeles Resident General Surgery Physician and researcher within the Kaiser Permanente and UCLA health systems – presented “data from a new multi-center retrospective cohort study that identifies the optimal time from non-small cell lung cancer (NSCLC) diagnosis to surgery to reduce mortality” during the American Association for Thoracic Surgery’s 104th Annual Meeting. Velotta, MD, FACS, an AATS member and Kaiser Permanente Bernard J. Tyson School of Medicine Professor of Clinical Science, is the principal investigator of the study.

The findings may be helpful to physicians who have struggled to advise patients on the best time to schedule surgery to avoid the spread of cancer because of the mixed bag of data available with varying diagnosis dates and due to a lack of standardized guidelines around timing related to surgery performance.

Dr. Jeffrey Velotta attends the AATS 104th Annual Meeting.

Dr. Jeffrey Velotta attends the AATS 104th Annual Meeting.

The research team followed a large, diverse group of patients with clinical stage I–II NSCLC who underwent surgical resection without neoadjuvant therapy between 2009 and 2019, to determine long-term mortality rates. They looked specifically at varied time points between diagnosis and surgery – 2, 4, 6, 8, 10, and 12 weeks in 2,567 early-stage patients – and found that long-term mortality decreased and survival was improved for patients treated within eight weeks. After eight weeks, nearly a 20 percent mortality increase was discovered at five years. If the patient waited longer, such as 10 to 12 weeks, mortality increased as high as 31 percent. 

The study’s findings made it clear that the longer patients waited for treatment, the worse their condition became. With this in mind, Dr. Velotta is not only advocating for patients to be treated faster, but he also supports the establishment of a standard diagnostic point for lung cancer, which would incentivize speedier treatments for patients.