Ka-Man (Ivy) Law, PhD



Biomedical Science

Ka-Man (Ivy) Law, PhD, is a researcher in Immunology, Endocrinology and Gastroenterology with extensive experience in medical education and mentoring. She previously served at the Division of Digestive Diseases in the Department of Medicine at UCLA. Her research interest focuses on pathophysiology of Inflammatory Bowel Disease (IBD), with a special focus on inflammatory response in colonic epithelial cells. She has also studied non-coding RNA, including micro-RNAs, long non-coding RNAs, and their role in epithelial cell biology. She has published more than 20 research articles in peer-reviewed journals including Gut, Scientific Reports, and Journal of Biological Chemistry. She is a member of the American Gastroenterological Association.

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Education and Training

BSc, University of Hong Kong
MPhil, University of Hong Kong
PhD, University of Hong Kong
Postdoctoral training
Postdoctoral Fellow, UCLA

Professional Positions

Assistant Project Scientist
UCLA Department of Medicine
Tutor, Problem-based Learning, Case-based Learning
UCLA Department of Medicine
Instructor, Biomedical Science
Kaiser Permanente Bernard J. Tyson School of Medicine

Honors and Awards

Fellowship Research Award
Crohn's and Colitis Foundation
Career Development Award
Crohn's and Colitis Foundation
Young Investigator Award
Crohn's and Colitis Foundation

Scholarly Activities

Peer-reviewed research manuscripts
  • Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y (2009) Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. Proteomics 9(9):2444-56
  • Law IK, Xu A, Lam KS, Berger T, Mak TW, Vanhoutte PM, Liu JT, Sweeney G, Zhou M, Yang B, Wang Y (2010) Lipocalin-2 deficiency attenuates insulin resistance associated with ageing and obesity. Diabetes 59(9):872-82
  • Law IK, Murphy JE, Bakirtzi K, Bunnett NW, Pothoulakis C. (2012) Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1 dependent endocytosis and resensitization of neurotensin receptor 1. J Biol Chem 287(18):15066-75
  • Law IK, Bakirtzi K, Polytarchou C, Oikonomopoulos A, Hommes D, Iliopoulos D, and Pothoulakis C. (2015) Neurotensin – regulated miR-133α is involved in proinflammatory signaling in human colonic epithelial cells and in experimental colitis. Gut. 64(7):1095-1104.
  • Law IK, Jensen D, Bunnett NW, Pothoulakis C. (2016) Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin. Sci Rep. 6: 22195.
  • Law IKM, Padua DM, Iliopoulos D, Pothoulakis C. (2017) Role of G protein-coupled receptors-microRNA interactions in gastrointestinal pathophysiology. American Journal of Physiology-Gastrointestinal and Liver Physiology. 313(5):G361-G372 
  • Bakirtzi K*, Law IKM*, Fang K, Iliopoulos D, Pothoulakis C. (2019) MiR-21 in Substance P-induced exosomes promotes cell proliferation and migration in human colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 317(6):G802-G810
Book chapters
  • Law IK, Cheng MW, Shih DQ, McGovern DP, Koon HW. The roles of antimicrobial peptides in the regulation of gastrointestinal microbiota and innate immunity. In: Antimicrobial peptides in gastrointestinal diseases. 1 ed. Cho CH, editor. San Diego, CA, United States: Academic Press, Elsevier; 2018. Chapter 3; p.35-54.